CLINICAL TRIALS AND OBSERVATIONS A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with -thalassemia
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چکیده
Maria Domenica Cappellini, Alan Cohen, Antonio Piga, Mohamed Bejaoui, Silverio Perrotta, Leyla Agaoglu, Yesim Aydinok, Antonis Kattamis, Yurdanur Kilinc, John Porter, Marcello Capra, Renzo Galanello, Slaheddine Fattoum, Guillermo Drelichman, Carmelo Magnano, Monica Verissimo, Miranda Athanassiou-Metaxa, Patricia Giardina, Alexandra Kourakli-Symeonidis, Gritta Janka-Schaub, Thomas Coates, Christiane Vermylen, Nancy Olivieri, Isabelle Thuret, Herbert Opitz, Catherine Ressayre-Djaffer, Peter Marks, and Daniele Alberti
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Effect of transfusional iron intake on response to chelation therapy in -thalassemia major
The success of chelation therapy in controlling iron overload in patients with thalassemia major is highly variable and may partly depend on the rate of transfusional iron loading. Using data from the 1-year phase III study of deferasirox, including volumes of transfused red blood cells and changes in liver iron concentration (LIC) in 541 patients, the effect of iron loading on achieving neutra...
متن کاملPlenary Paper CLINICAL TRIALS AND OBSERVATIONS A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in b-thalassemia major (CORDELIA)
A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in b-thalassemia major (CORDELIA) Dudley J. Pennell, John B. Porter, Antonio Piga, Yongrong Lai, Amal El-Beshlawy, Khawla M. Belhoul, Mohsen Elalfy, Akif Yesilipek, Yurdanur Kilinç, Tomasz Lawniczek, Dany Habr, Marianne Weisskopf, Yiyun Zhang, and Yesim Aydinok, on behalf of the CORDELIA study invest...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)
Stroke is a devastating complication of sickle cell anemia (SCA) with high recurrence if untreated. Chronic transfusions reduce recurrent strokes but have associated morbidities including iron overload. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) was a multicenter phase 3 randomized trial comparing standard treatment (transfusions/chelation) to alternative treatment (hydroxyurea/p...
متن کاملCLINICAL TRIALS AND OBSERVATIONS A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload
1Children’s Hospital, Harvard University, Boston, MA; 2Università degli Studi di Cagliari, Cagliari, Italy; 3Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4Pediatric Haematology, Ege University Hospital, Izmir, Turkey; 5Scienze Cliniche e Biologiche, Torino, Italy; 6Gastroenterology, Children’s Hospital & Research Center Oakland, Oakland, CA; 7Centro della Microcitemia e delle Anemia...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study
1American University of Beirut, Beirut, Lebanon; 2University College London, London, United Kingdom; 3Department of Pediatrics and Internal Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4First Department of Pediatrics, University of Athens, Athens, Greece; 5Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 6Chulalongkorn University and King Chulalongkorn Memorial...
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تاریخ انتشار 2006